Preheat your grill to medium-high heat. If needed, clean the grill grates.
Divide the meat into 4 portions and form burger patties, about ½ to ¾ inch thick and slightly larger than the size of the buns (they will shrink when cooking). Make a slight indentation or depression in the center of each patty, and if needed, press around the edges a few times to smooth it out. This will prevent them from puffing up in the center.
Season each side of a burger patty with ⅓ teaspoon of my homemade seasoning blend. Alternatively, you can season with salt and pepper only.
Grill the burgers: Cook the burgers to your liking. For medium-well, cook about 4 minutes per side, adding the slice of cheese during the last 1 minute. For more cooking times, see the recipe notes below. Tips: Do not press down o the burgers, as this can squeeze out all the juices.
Build the burgers. If desired, toast the buns on the grill first. I usually build them in this order: bottom bun, mayo (or any sauce), tomato, onion, lettuce, ketchup and mustard, and the top bun.